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each hazardous chemical or particularly hazardous substance that will be addressed in the SOP should be referenced during SOP development. The SDS lists important information that will need to be considered, such as exposure limits, type of toxicity, warning properties, and symptoms of exposure. If a new chemical will be produced during the experiment, an SDS will not necessarily be available. In these cases, the toxicity is unknown and it must be assumed that the substance is particularly hazardous, as a mixture of chemicals will generally be more toxic than its most toxic component. While general guidance regarding laboratory work with chemicals is contained in this plan, Faculty/Other Laboratory Supervisors are required to develop and implement laboratory-specific SOPs for certain hazardous chemicals and PHS that are used in their laboratories. These SOPs must be submitted and reviewed by the Primary Investigator prior to implementation. For certain hazardous chemicals, PHS, or specialized practices, consideration must be given to whether additional consultation with safety professionals is warranted or required. Secondary containment must be

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